• It is noteworthy that in a recent study Le Scouarnec

  2019-06-28

  

  It is noteworthy that in a recent study, Le Scouarnec et al. [199]. estimated the burden of rare coding variation in arrhythmia susceptibility genes among 167 BrS index patients and compared that with 167 individuals ≥65 years old with no history of cardiac arrhythmia. The authors concluded that, ex

• An ERP in the ECG has

  2019-06-28

  

  An ERP in the ECG has been shown to be familial [187–189]. ERP and ERS have been associated with variants in 7 genes. Consistent with the findings that IK-ATP activation can generate an ERP in canine ventricular wedge preparations, variants in KCNJ8 and ABCC9, responsible for the pore- forming and A

• The increasing complexity and demands of the proper

  2019-06-27

  

  The increasing complexity and demands of the proper diagnosis and management of patients with inherited cardiovascular disease create an opportunity for the development of specialized training for clinical electrophysiologists interested in the care of patients with inherited arrhythmias [229]. Such

• Heat shock facilitates the folding of various proteins as me

  2019-06-27

  

  Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is

• GSK1210151A El juego de las apariencias y la obtenci

  2019-06-27

  

  El juego de las apariencias y la obtención de un estatus no son privativos de los consumidores del arte en este texto: coleccionistas, guías de museo o críticos improvisados. El cuento “Borges y el ultraísmo”, también del libro Amores de segunda mano (1991), ubicará la discusión directamente en los

• CVT-313 The region is also suffering from administrative

  2019-06-27

  

  The region is also suffering from administrative negligence, extreme poverty, lack of basic health facilities, and weak infrastructure, which have increased its vulnerability to the climatic misery. Travel time to the nearest health facility is 2–4 h, at a cost of PKR 1000–4000 (US$10–40) in a regio

• Pentostatin of br ALANISMO E IZQUIERDA UNIDA

  2019-06-27

  

  ALANISMO E IZQUIERDA UNIDA No plano político, o desmoronamento da iu está associado às ambiguidades com que se relacionou com a primeira força política do país neste momento, o apra e o presidente Alan García. Especificamente, o grupo em torno de Alfredo Barrantes acreditou em um cenário de alter

• br CUANDO EL CUERPO SE HACE ESPACIO

  2019-06-27

  

  CUANDO EL CUERPO SE HACE ESPACIO El punto en común de estos lienzos es la ausencia de mirada (figuras 3a y 3b). En el primero los ojos están negros, se presentan las dos órbitas vacías; en el segundo están deliberadamente borrados, ya que incluso se puede distinguir por debajo el contorno de los

• I received a grant from The Kendeda

  2019-06-27

  

  I received a grant from The Kendeda Fund to write and promote my book, , on which this comment is based. I thank Richard King (Chatham House, London, UK) for data assistance, Christian Guthier (All is Possible, Oxford, UK) for graphic design, and Sarah Cornell (Stockholm Resilience Centre, Stockholm

• WAY-100635 molecular Findings children from households were

  2019-06-27

  

  Findings 5254 children from 3376 households were enrolled either at baseline or during the trial period. Mean 20-h kitchen concentration of PM2.5was reduced from 1386 μg/m3 to 930 μg/m3 There was a strong secular decline in the incidence of ALRI over the period of the study. The intervention was ass

• Evidence supporting the benefit of dexrazoxane

  2019-06-26

  

  Evidence supporting the benefit of dexrazoxane as cardioprotective therapy in adults with acute leukemia are scant [11]. However, there is a significant need for cardioprotective therapy, particularly in older individuals with preexisting cardiovascular disorders and/or prior anthracycline exposure,

• In an earlier study we used a

  2019-06-26

  

  In an earlier study, we used a questionnaire to assess musculoskeletal pain in patients with CML who had achieved DMR (MR4.0) and discontinued TKI treatment, including IM, nilotinib, and dasatinib [5]. Nine out of the 27 patients surveyed developed musculoskeletal pain after discontinuing TKIs. In t

• ASC-J9 molecular For most health care professionals infectio

  2019-06-26

  

  For most health-care professionals, infectious-disease modelling is something of a black box. One can see the input assumptions (ie, what goes in) and the outputs (ie, what comes out), but what happens in between seems close to magic. Given their complexity, to understand any one of the models used

• The imbalances in the current R

  2019-06-26

  

  The imbalances in the current R&D system were the subject of the 2012 report of WHO\'s Consultative Expert Working Group on Research and Development (CEWG). The CEWG recommended a global binding agreement that provides a needs-driven and evidence-based framework for R&D, guided by the core principle

• br Future potential cardiac examinations

  2019-06-26

  

  Future potential cardiac examinations for long-duration spaceflights Currently available treatments for emergency cases in spaceflight Astronaut Crew Medical Officers (CMO) aboard the ISS receive 40–70h of medical training, including CPR training, within 18 months preceding their mission (Fig.

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