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To show the reactivity of our FMD agents with
2018-10-23
To show the reactivity of our FMD agents with antioxidants in human normal and cancer cells, we measured the intracellular reduced glutathione (GSH) levels of both human normal cells (GM05757) and human cervical cancer cells (ME-180) in control (with no FMDs) and treated by various concentrations of
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Previous work on a limited scale
2018-10-23
Previous work, on a limited scale compared to Yu et al.\'s, has also sought to explore the mutational spectrum of lung cancer tissues in Xuanwei. A small exploratory study among 40 never smoking females who had NSCLCs from Xuanwei had mutations detected in 35% of tumors (). mutations were observed
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DCM based markers of effective connectivity between pre spec
2018-10-23
DCM-based markers of effective connectivity between pre-specified regions of the motor network also did not indicate any compensation. However, it should be noted that DCM is limited by the necessity to specify regions a priori, and untested compensatory mechanisms involving phalloidin areas not inc
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In this study we investigated
2018-10-23
In this study, we investigated changes in MMP concentrations on ART and the association between these changes and paradoxical TB-IRIS in a well-characterized cohort of HIV-infected adults with advanced HIV/TB (Ravimohan et al. 2013; Ravimohan et al. 2015a). Furthermore, in a subset of patients, we e
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br Limitations Though the use
2018-10-23
Limitations Though the use of organ- or tissue-on-a-chip devices shows a great deal of promise for future applications, it is important to remember that these are relatively new technologies and require further advancements prior to widespread use. It is first necessary to characterize these devi
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Ion Channel Compound Library Seventy one individuals aged wi
2018-10-23
Seventy one individuals aged C p.(Trp777Arg); c.3610C>G p.(Arg1204GIy); c.4016T>G (p.Leu1339Arg); c.4267A>G p.(Lys1423Glu); c.5425C>T p.(Arg1809Cys); c.6950T>C p.(Leu2317Pro); and also an in frame Ion Channel Compound Library not present in the parents lymphocyte DNAs (c.3327_3329del p.(Leu1109del)
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It is generally agreed that
2018-10-23
It is generally agreed that R5 variants give rise to R5X4 viruses, which can further evolve to X4 HIV-1 (Pastore et al., 2004). Specific modifications in the envelope glycoprotein (env) variable loop 3 (V3), which binds the co-receptor, are required for the transition from R5 to X4 virus (Huang et a
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In this issue of Proietti and
2018-10-23
In this brucine issue of , Proietti and colleagues () analyzed pooled datasets (n=3646) from SPORTIF III and V trials of warfarin-treated patients dependent on renal function. Diminished creatinine clearance (70%, whilst diabetes mellitus, aspirin use and RI were inversely associated with TTR>70%.
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An ongoing phase I II
2018-10-23
An ongoing phase I/II trial (NCT02285816) is testing this two virus oncolytic vaccine approach in solid tumours expressing the MAGE-A3 tumour antigen. Oncolytic Viruses: Repolarizing and Manipulating the Tumour Microenvironment The immune suppressive microenvironment that supports malignant cell
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Introduction In st century the century
2018-10-23
Introduction In 21st century, the century when the humanity hopes to embark on interplanetary travel, we are yet to fully reach an understanding of our very own idiosyncratic terra incognita – the human sleep. Sleep is a highly conserved evolutionary process that constitutes approximately one third
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Another limitation of this study
2018-10-23
Another limitation of this study relates to how metabolic change in response to fasting differs among species. For example, in a recent report, lipidomic analysis of human and animal plasma showed that lipid metabolism differed markedly between humans and rats during fasting (Ishikawa et al., 2015).
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br Concluding Remarks br Financial Disclosures br Author
2018-10-23
Concluding Remarks Financial Disclosures Author Contributions Role of the Funding Source Partial funding for this study was provided by a service directed grant from the U.S. Department of Veterans Affairs and the University of Minnesota (Brain and Genomics Fund and the American Legion B
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In this study we are unable
2018-10-23
In this study we are unable to estimate the contribution of environmental factors to schizophrenia risk. We interpret the overall higher risk in MZ twins (in all our results) as indication of the importance of genetic factors according to the classical twin model (Boomsma et al., 2002). Furthermore,
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br Acknowledgments We thank the Gebze Technical University G
2018-10-23
Acknowledgments We thank the Gebze Technical University (GTU) research fund for partial support. Materials and methods Conflict of interest Acknowledgement We thank the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan for the financial support. Value of
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br Experimental design materials and methods The synthesis w
2018-10-23
Experimental design, materials and methods The synthesis was carried out as described previously [1]. “Krokodil extract” samples were obtained by the treatment of 4mL of crude “krokodil” with NaOH 20% (m/v) until alkalization, followed by extraction with ethyl acetate. The organic phases were gat
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