• Overall ten genes five of which are coding genes

  2018-10-24

  

  Overall, ten genes, five of which are coding genes (FMOD, SULF1, COL12A1, STMN2 and MAEL), and five long-non-coding RNA (lncRNA) genes, were differentially expressed in hUC cells. lncRNAs are non-protein coding transcripts longer than 200 nucleotides. They have been implicated in the regulation of g

• Importantly we found that both

  2018-10-24

  

  Importantly, we found that both HIF factors nonredundantly regulate the morphology and behavior of primary mesenchymal progenitors: in the absence of HIFα expression PαS+ mesenchymal progenitors show impaired proliferation, colony forming ability, and differentiation and acquire an elongated and mot

• With these results we provide evidence that

  2018-10-24

  

  With these results, we provide evidence that the transplantation of iPSC-derived NSCs could have a beneficial role in modifying the course of SMARD1. Regarding the translational safety of iPSC-derived cells, one major finding of this study is that adverse events such as tumorigenesis or abnormal gro

• It is intriguing that all surviving germ cells

  2018-10-24

  

  It is intriguing that all surviving germ cells in Ret mutant mice expressed GFRA1. It is possible that GFRA1 was upregulated to compensate for the reduction of GDNF signaling. Because of the controversy on GFRA1 expression on SSCs, we performed FACS experiments to explore the relationship between GF

• br Author Contributions br Acknowledgments br Introduction N

  2018-10-24

  

  Author Contributions Acknowledgments Introduction Neurons in the CNS are particularly sensitive to injury and degenerative conditions that frequently result in cell death. Although adult neurogenesis persists in restricted transferase areas (Gage, 2000; Hsieh, 2012; Kriegstein and Alvarez-

• Since the discovery of these cells Ingram et al

  2018-10-24

  

  Since the discovery of these tankyrase (Ingram et al., 2004), secondary colonies have been generated in several studies to assess the immaturity of ECFCs from blood or vascular wall and hierarchize them (Alphonse et al., 2015; Ingram et al., 2005; Patel et al., 2016). The aim of this work was to id

• Unlike the LMW FGF isoform which is well studied the

  2018-10-24

  

  Unlike the LMW FGF2 isoform, which is well-studied, the HMW isoforms of FGF2 are not nearly as well-understood, but recent reports have investigated the effects of HMW FGF2 signaling in various contexts. Localization of FGF2 isoforms can vary depending on cellular conditions and stimuli (Arese et al

• br Results br Discussion Our studies highlight the potential

  2018-10-24

  

  Results Discussion Our studies highlight the potential clinical significance of the iC9 safeguard system. Recent studies introducing suicide gene-based safeguard systems into mouse or rhesus iPSCs report that teratoma formation was significantly delayed or inhibited only when treatment started

• It is known that synuclein

  2018-10-24

  

  It is known that α-synuclein is degraded in part by the autophagic/lysosomal pathway (Cuervo et al., 2004). We observed no differences for the intracellular α-synuclein levels in dopaminergic cultures derived from three patients carrying the GBA-N370S mutation, which is in line with the report of Sc

• Conversely not much is known

  2018-10-24

  

  Conversely, not much is known about the origin of these mutations. Their high frequency, combined with the proficient DNA repair of hESC (Sokolov and Neumann, 2013), suggests that these lpa receptor undergo profuse DNA damage in culture. Studies on genetic mosaicism in hESC cultures, which reflect

• The fact that the in vitro induction of

  2018-10-24

  

  The fact that the in vitro induction of osteogenic differentiation leads to sarcoma development from sarcoma iPSCs in concert with EWS-FLI1 expression indicates that these sarcomas arise from osteogenic progenitor cells. However, it is important to note that the withdrawal of EWS-FLI1 in osteosarcom

• formyl peptide receptors The experimental design of this

  2018-10-24

  

  The experimental design of this model provides several differences to standard 2D culture: EHTs are anchored between two flexible silicone posts, which generate a preload, and EHTs perform auxotonic contractile work (the physiological form of cardiac contraction) against elastic posts. This results

• Collectively our studies have demonstrated

  2018-10-24

  

  Collectively, our studies have demonstrated a paradigm for direct conversion of multipotent iENPs from human somatic amphetamine sulfate through overexpression of hESC-NP-enriched TFs. This system will allow generation of expandable iNP populations with desirable neural differentiation propensities

• rock pathway In summary our findings identified legumain as

  2018-10-24

  

  In summary, our findings identified legumain as a “molecular switch” with opposing effects on bone and fat formation by hBMSCs through degradation of the ECM protein fibronectin (Figure 6F) and that altered expression of legumain in the bone microenvironment contributes to the pathophysiology of tra

• In addition recent findings indicate that the majority of

  2018-10-24

  

  In addition, recent findings indicate that the majority of in vitro expanded cells undergo apoptosis upon implantation (Stegen et al., 2016). A cause may be the need to instantly adjust to a compromised environment, since current culture conditions represent a rather non-physiological and abundant n

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