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Finally we observed decreased leukocyte influx in
2018-10-29
Finally, we observed decreased leukocyte influx in exosome treated animals. It is likely that the reduced influx is secondary to the reduced cardiac injury after exosome treatment, since leukocyte influx did not differ between the groups at 1h reperfusion. In addition, we found that the reduced infa
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Besides muscle satellite cells several muscle progenitor
2018-10-29
Besides muscle satellite cells, several muscle progenitor mu opioid receptor antagonist have been identified so far among which are blood-vessel associated myo-endothelial cells (Zheng et al., 2007; Crisan et al., 2008), meso-angioblasts (Minasi et al., 2002) and muscle-derived stem cells (MDSCs) (
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The effect of taurine increasing NPC number may result from
2018-10-29
The effect of taurine increasing NPC number may result from a protective action improving cell viability or/and from an increase in proliferation. This was examined by measuring viability by the Trypan blue exclusion and MTT assays, and proliferation by BrdU incorporation. Fig. 2A shows the time cou
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br Results and Discussion br Experimental
2018-10-29
Results and Discussion Experimental Procedures Acknowledgments Introduction Insights into potential mechanisms for the regulation of mammalian tissue repair have come from studies of animals that can regenerate limbs, tails, and even the spinal cord, such as order Cy3.5 hydrazide and re
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br Materials and methods br Results br Discussion Currently
2018-10-29
Materials and methods Results Discussion Currently, a number of cell types such as EPCs, bone marrow mononuclear cells, and mesenchymal stromal MK1775 are being tested in clinical trials for their efficacy in treating cardiovascular diseases (O\'Neill et al., 2012). Although there appears
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MicroRNAs miRNAs are small non coding RNAs which regulate
2018-10-26
MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression in a post-transcriptional manner. A recent study reported that ZEB1, another EMT activator, can directly suppress the transcription of miR-141, miR-200c, and miR-203 by interacting with their respective promoter regions. Mor
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The mammalian myocardial response to increased
2018-10-26
The mammalian myocardial response to increased workload and to injury is conditioned by the fact that, shortly after the post-natal period, CMs permanently withdraw from the cell cycle (Nadal-Ginard., 1978). The molecular mechanism of terminal differentiation in CMs has not yet been completely defin
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Our group recently reported a model system which allows
2018-10-26
Our group recently reported a model system, which allows to effectively screen whole miRNA libraries for miRNA candidates modulating reprogramming efficacy (Pfaff et al., 2011). Utilizing this model, we previously have identified a miRNA family consisting of miR-130b, miR-301b, and miR-721 strongly
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br Materials and methods br Results br Discussion We have
2018-10-26
Materials and methods Results Discussion We have previously shown that cellular phenotype is an important determinant of the malignant potential in human neuroblastoma Z-YVAD-FMK and tumors (Walton et al., 2004). In particular, in those experiments, we identified a stem cell phenotype in h
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purchase Monastrol Since the production of lactic acid
2018-10-26
Since the production of lactic purchase Monastrol seems to be the cause of the genotoxic stress, modifying the culture medium could control its production and its effects. Because hESC do not metabolize carbon sources such as fructose or galactose, which generate less lactate, an option could be to
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Below we highlight what has been preserved and what is
2018-10-26
Below, we highlight what has been preserved and what is new in the 2016 ISSCR Guidelines for Stem Cell Research and Clinical Translation. We also provide a window into our deliberations and describe key elements of the process from which these revised guidelines emerged. Specific recommendations emb
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flt3 The combination of colors In single pass CCD
2018-10-26
The combination of colors. In single-pass CCD scanners the color of the falling light is registered by three photodetecting linear arrays that cannot be absolutely identical due to technological variance and therefore may render a distorted image. Analysis of scanned images The scanner breaks th
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br Acknowledgments Supported by the Russian
2018-10-26
Acknowledgments Supported by the Russian Foundation for Basic Research (Grants 07-06-00263-а, 10-06-00114-а, and 13-06-00042-а), and by the Russian Foundation for Humanities (Grants 06-06-00375-a and 12-06-18001-e). The author is indebted to Dr Vladislav Palchikov, Dr Konstantin Danilenko, Dr Evg
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We described the presence of dye and electrical
2018-10-26
We described the presence of dye and electrical coupling in the RAS, specifically in the intralaminar parafascicular nucleus (Pf), the PPN, and the subcoeruleus dorsalis (SubCD), which modulates REM sleep [42–44]. We also found that the stimulant modafinil decreased the resistance of PPN, Pf, and Su
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Two experienced sleep scorers one board certified evaluated
2018-10-26
Two experienced sleep scorers (one board certified) evaluated seven hours of recording. The recording contained 6h and 45min of sleep preceded by 15min of wakefulness. Both scorers analysed first the standard EEG motilin receptor then repeated the process looking exclusively at the intra-ear and in
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