• Previous studies reported that NE and MHPG are

  2020-07-28

  

  Previous studies reported that NE and MHPG are deeply involved in depression and that NE reuptake inhibitors are approved for use in patients with depression (for review, see [2]). We found increased hippocampal content of NE and MHPG in the CORT-treated CRTH2−/− mice (Fig. 3). In the hippocampus,

• br Materials and methods br Results br Discussion Consistent

  2020-07-28

  

  Materials and methods Results Discussion Consistent with previous reports (Barr et al., 2010, Vuong et al., 2010), the current study demonstrates that rats treated with amphetamine exhibit heightened anxiety states during withdrawal. Furthermore, icv. infusion of a CRF2 receptor antagonist

• Another stream of chiller system models focused on FDD Yan

  2020-07-28

  

  Another stream of chiller system models focused on FDD. Yan et al. (2018) used a back-tracing sequential forward feature selection algorithm to select the most significant features for FDD and then used the support vector machine for measuring accuracy. Li and Hu (2018) considered the density-based

• The remainder of this paper is organized as

  2020-07-28

  

  The remainder of this paper is organized as follows: Section 2 provides background on previous research about SE for scientific software. Section 3 describes the research methodology used in this systematic literature review. Section 4 reports the scientists’ and software engineers’ claims about SE

• br Discussion In fact the drugs cancer link

  2020-07-27

  

  Discussion In fact, the drugs-cancer link is not straightforward. Several anticancer drugs increase ROS production (Peng and Gandhi, 2012), which creates hypoxia (McKeown, 2014). It favors the tumors, as they are adapted to survive in hypoxic conditions (Rockwell et al., 2009, McKeown, 2014). The

• Alternation of joints by mechanical stress produces

  2020-07-27

  

  Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides mitotic inhibitors for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocytes in the injured cartilage releases transforming growth fa

• DDR is widely expressed in

  2020-07-27

  

  DDR1 is widely expressed in several tissues (Alves et al., 1995, Curat & Vogel, 2002, Ferri et al., 2004, Hou et al., 2001, Mohan et al., 2001, Sakamoto et al., 2001, Tanaka et al., 1998) including the mouse (Bhatt et al., 2000, Franco-Pons et al., 2009, Sanchez et al., 1994, Seo et al., 2008, Zerli

• The term myeloproliferative disorders was first proposed by

  2020-07-27

  

  The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myeloproliferative dis

• From the same perspective previous studies by

  2020-07-27

  

  From the same perspective, previous studies by Sajdyk and colleagues (Sajdyk et al., 1999) and Spiga and colleagues (Spiga et al., 2006) have shown that the administration of CRF or urocortin 1 (a selective agonist for CRF1 and CRF2 receptors but with a higher affinity for the CRF1 receptor) into th

• br Results and discussion br

  2020-07-27

  

  Results and discussion Conclusions The results of KKR and KKR-CPA electronic structure calculations were presented for LiMO2 compounds and LiNiCoMn0.1O2 solid solutions, respectively. It was found that Mn impurity located in semiconducting LiCoO2 matrix might exhibit magnetic moment. The mixin

• Pulmonary fibroblasts can regulate the wound

  2020-07-25

  

  Pulmonary fibroblasts can regulate the wound healing process by secreting and processing extracellular matrix (ECM), chemokines, and cytokines. However, persistent and atypical fibroblast proliferation can result in ECM accumulation and may trigger the onset or development of pulmonary fibrosis [[17

• In we studied normal rational varieties X of complexity one

  2020-07-25

  

  In [1] we studied normal, rational -varieties X of complexity one, where the latter means that X comes with an effective torus action such that holds. We showed that for affine X with and at most log terminal singularities, the iteration of Cox rings is possible. In the present article, we charac

• In humans individual differences in prefrontal dopamine are

  2020-07-25

  

  In humans, individual differences in prefrontal dopamine are partially caused by the Val158Met single-nucleotide polymorphism on the catechol-O-methyltransferase gene (COMT). This gene controls activity of the COMT enzyme, which degrades extracellular catecholamines including dopamine. The Val varia

• The interferences between thapsigargin and forskolin induced

  2020-07-25

  

  The interferences between thapsigargin- and forskolin-induced Ca release indicate that these drugs deplete the same intracellular stores in RASMC. In fact, after partial depletion of thapsigargin-sensitive stores, the forskolin-induced increases in [Ca]c were significantly reduced. Similarly, a prev

• akt pathway Our results indirectly support the combination

  2020-07-25

  

  Our results indirectly support the combination of resveratrol and hesperatin treatment for PDN, as this induces GLO1 activity in patients (Xue et al., 2016), as well as metformin, an FDA-approved anti-diabetic treatment, which acts as an MG scavenger to reduce MG levels in type 2 diabetic patients (

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