• Activation of FXR or TGR inhibits inflammatory response

  2021-09-14

  

  Activation of FXR or TGR5 inhibits inflammatory response via repressing NF-κB activity [1]. FXR is not expressed or expressed at a very low level in macrophages [45] (data not shown), but highly expressed in hepatocytes. In contrast, TGR5 is expressed in macrophages but not in hepatocytes. Our data

• br Material and methods br Results br

  2021-09-14

  

  Material and methods Results Discussion In the present study, we attempted to unravel the mechanism underlying the statin-mediated inhibition of FGFR3 signaling in chondrocytes, reported earlier by Yamashita and colleagues. We evaluated the role of statins in four different experimental sys

• br Acknowledgements br Introduction Muscle FBPase is

  2021-09-14

  

  Acknowledgements Introduction Muscle FBPase is very sensitive to AMP inhibition and in the presence of physiological concentrations of this effector in muscle fibres FBPase should be almost completely inactive [1], [2]. Recently, we have presented evidence that, in vitro, muscle aldolase binds

• At the molecular level AZ

  2021-09-14

  

  At the molecular level AZ scaffold proteins including piccolo and bassoon have been shown to directly or indirectly associate with endocytic and actin-binding proteins such as ABP1 (Fenster et al., 2003), profilin, and GIT (Podufall et al., 2014) (Fig. 2B). ABP1 and profilin, via regulating F-actin,

• Previous studies have attributed the changes that

  2021-09-14

  

  Previous studies have attributed the changes that occurs during the behvioral sensitization to many psychostimulants with neuroadaptation in dopaminergic cell bodies of the VTA (induction phase) along with alteration in dopamine axon terminal field transmission of NAc during the expression to sensit

• Relative to the impact of

  2021-09-14

  

  Relative to the impact of moderate PAE on markers of histaminergic neurotransmission, there were four salient observations from the studies reported here. First, it does not appear that moderate PAE affects the number of HDC-positive neurons in the tuberomammillary nucleus of the ventral hypothalamu

• chembridge mg Allergic rhinitis characterized by inflammatio

  2021-09-14

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to chembridge mg in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering allergic

• Spatial working memory improved in the Balb c strain

  2021-09-14

  

  Spatial working memory improved in the Balb/c strain at a dose of VU0410120 (i.e., 30mg/kg) that disrupted spatial working memory in the Swiss Webster comparator strain. Consistent with a recent PET study in rhesus macaques suggesting a relationship between the extent of the dose-dependent occupancy

• br Vesicular glutamate transporters VGLUTs br Conclusions Du

  2021-09-14

  

  Vesicular glutamate transporters (VGLUTs) Conclusions Due to the molecular cloning of EAAT and VGLUT subtypes, a better understanding of the functional properties of these carriers has been elucidated over the last few years. In the case of the EAATs, specific blockers, such as trans-2,4-PDC,

• The possibility of having false positives even if minimized

  2021-09-13

  

  The possibility of having false positives, even if minimized, is always present and requires that a reactive result should be followed by a confirmation test. Traditionally, Western blot (WB) has been used, but various types of immunoblotting that use recombinant conotoxin mg or synthetic peptides

• To promote biomimetic growth of HAp Li et

  2021-09-13

  

  To promote biomimetic growth of HAp, Li et al. [20] developed a technique to modify cellulose nanofibers using P2O5. It was ascertained that the negative phosphate groups bonded with Ca2+ through coordination bonds and subsequently guided the growth of the Ca–P crystals throughout the scaffolds. Sim

• nicotinic acetylcholine receptor The fact that KNDy neurons

  2021-09-13

  

  The fact that KNDy neurons activity is sensitive for circulating hormones related with control of nicotinic acetylcholine receptor homeostasis was demonstrated in other studies (Cejudo Roman et al., 2012; Navarro et al., 2011). It is well documented that leptin plays an important role in the regula

• br Acknowledgements This work was supported

  2021-09-13

  

  Acknowledgements This work was supported by the grants from National key Basic Research Program of China (2012CB124702), 948 Program (2015-Z33), National Natural Science Foundation of China (31172093, 31301947), the National Science Foundation for Fostering Talents in Basic Research (J1103510), S

• After ischemia expression of transcription factors including

  2021-09-13

  

  After ischemia, expression of transcription factors, including products of immediate early genes, stress proteins and neurotrophic factors are also altered in CA1 neurons78, 79. These proteins are potential candidates for downregulating of GluR2 expression by reducing mRNA transcription or stability

• The potential therapeutic actions of

  2021-09-13

  

  The potential therapeutic actions of GHSR in the central nervous system has been in the limelight lately. Peripheral administration of GHSR agonists have been shown to inhibit oxidative stress, apoptosis, proinflammatory cytokine production, microglia activation, mitochondrial dysfunction, and excit

15741 records 559/1050 page Previous Next First page 上5页 556557558559560 下5页 Last page