• Uracil DNA glycosylase UDG is a highly conserved damage repa

  2021-11-24

  

  Uracil-DNA glycosylase (UDG) is a highly conserved damage repair enzyme which can specifically recognize and excise uracil residue within the DNA sequences and actuate the DNA PFI-2 excision repair (BER) pathway which keeps the maintenance of genomic integrity and stability [[21], [22], [23]]. Howe

• br Other strategies for ferroptosis In addition

  2021-11-24

  

  Other strategies for ferroptosis In addition to ROS-generating and GPX4 inactivating nanomaterials, small molecules and genetic manipulation targeting key factors in the ferroptosis pathway have also been tested for their anticancer effects [39,47,48]. Among a myriad of proteins involved in ferro

• Thus aldolase catalyzing the reversible reaction

  2021-11-24

  

  Thus, aldolase catalyzing the reversible reaction of F1,6-P2 synthesis is involved in the formation of the glyconeogenic or glycolytic complex, dependently on the physiological state of the cell. In the process of glycogen synthesis, the enzyme not only supplies the substrate for FBPase and desensit

• Two US FDA approved assays are commonly used

  2021-11-24

  

  Two US FDA-approved assays are commonly used for VL monitoring: the COBAS AmpliPrep/COBAS® Taqman® HIV-1 version 2.0 (“CAP/CTM HIV-1 v2”; Roche Molecular Systems) [18], and the RealTime HIV-1 assay (“RealTime HIV-1”, Abbott Molecular) [19]. Several studies have shown good correlation between the ass

• Evidence demonstrating the interplay between hypoxia and

  2021-11-24

  

  Evidence demonstrating the interplay between hypoxia and the dynamics of histone methylation is mounting [15], [43]. For example, hypoxia leads to an increase in H3K4me3 by inhibiting their responsible demethylase [44]. Hypoxia also leads to an increase in H3K9me2 by upregulating the methyltransfera

• Although histamine can induce both proliferation and differe

  2021-11-24

  

  Although histamine can induce both proliferation and differentiation in vitro (Molina-Hernandez and Velasco, 2008), the promotion of neurogenesis conferred by H3R antagonism here does not seem to be caused by either the proliferation or the reduction of apoptosis of NSCs (Figure S3). Furthermore, H3

• br STAR Methods br Acknowledgments

  2021-11-24

  

  STAR★Methods Acknowledgments We thank P. Adler, V. Riechmann, N. Tapon, E. Knust, the Vienna Drosophila RNAi Center, the Australian Drosophila Research Support Facility (www.ozdros.com), the Bloomington Drosophila Stock Center, and the Developmental Studies Hybridoma Bank for D. melanogaster s

• br Results br Discussion In this study we found

  2021-11-24

  

  Results Discussion In this study, we found that ZNF280A was elevated in CRC tissues and a high expression of ZNF280A correlated with advanced clinicopathological features, poor prognosis, and disease progression in CRC patients. Furthermore, silencing ZNF280A attenuated proliferation and inhib

• FoxM a downstream target of Gli has

  2021-11-24

  

  FoxM1, a downstream target of Gli, has been mainly related to FITC, Fluorescein isothiocyanate regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase pro

• In contrast the sGC activator BAY relaxed

  2021-11-23

  

  In contrast, the sGC activator BAY 58-2667 relaxed the CC in a concentration-dependent manner (Figure 4B), a response that was significantly increased in the CC of sGCβ1ki/ki mice compared with WT mice. The finding that BAY 58-2667 also possessed a corporal relaxing effect in WT mice is suggestive b

• The frequency of GSTM and GSTT null genotypes

  2021-11-23

  

  The frequency of GSTM1 and GSTT1 null genotypes vary in different populations. For example, Hiragi et al. (2007) reported a frequency of 17–35% for the GSTM1 null genotype and 22–44% for the GSTT1 null genotype in Brazilians of African descent (Hiragi et al., 2007). Chen, Liu, and Relling (1996) rep

• The atherosclerosis development requires additional

  2021-11-23

  

  The atherosclerosis development requires additional pro-inflammatory response in the vascular tissue, promoting increased levels of adhesion molecules such as VCAM-1 (vascular cell adhesion molecule-1) and ICAM-1 (intercellular adhesion molecule-1). Cytokines such as TNF-α and IL-1β are able to upre

• Regarding the causative diseases of

  2021-11-23

  

  Regarding the causative diseases of ES, patients with unknown cause and those with encephalitis had significantly higher CSF levels of nf-κb inhibitor against GluN2B-NT2 and GluN2B-CT than the disease controls, but patients with genetic disorder and those with cortical dysplasia showed no significa

• br Introduction Glucose homeostasis is primarily regulated

  2021-11-23

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β GDC-0152 is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory horm

• LGX818 synthesis Mallory stained sections showed significant

  2021-11-23

  

  Mallory stained sections showed significant increase in collagen fiber deposition around the hepatic nodules together with significant increase in positive immune-reaction to α-SMA in TAA-treated group. This was in accordance with previous studies which reported that myofibroblasts which were develo

15741 records 516/1050 page Previous Next First page 上5页 516517518519520 下5页 Last page