• Urinary hydroxypyrene OHP is a

  2022-02-25

  

  Urinary 1-hydroxypyrene (1-OHP) is a widely used biological marker of exposure to PAHs and indicator for internal dose of activated PAHs (Jongeneelen, 1987, Adonis et al., 2003). PAH metabolites may be excreted either as free or as conjugated compounds. When 1-OHP is measured after treating the urin

• br Regulation of gonadotropins by GnRH GnRH is released

  2022-02-25

  

  Regulation of gonadotropins by GnRH GnRH is released from the hypothalamus, and its release pattern is known to be pulsatile. That is, the pulse frequency and amplitude of GnRH release vary physiologically during reproductive cycles in females, and differentially stimulate the production and rele

• br Conclusion br Conflict of interest statement br Acknowled

  2022-02-25

  

  Conclusion Conflict of interest statement Acknowledgements This work was supported by the National Science Foundation (MCB-1817417 to S.D.) and National Institutes of Health (R01-GM72711 to A.C.D.). We thank members of the Delaney laboratory for careful reading of the manuscript and helpful

• KW-6002 The role of the ER EK

  2022-02-25

  

  The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of KW-6002 levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might protect from the d

• The observed CORT induced increase in Cx phosphorylation at

  2022-02-25

  

  The observed CORT-induced increase in Cx43 phosphorylation at S368 may also contribute to GJIC disruption. Gap junction channel permeability is modulated through connexin phosphorylation (Moreno and Lau, 2007). Specifically, the phosphorylation of Cx43 on S368 has been previously shown to decrease i

• Cx mimetic peptides short synthetic peptides

  2022-02-25

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino PD 173074 sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a concent

• Although GABA C receptors were originally described in

  2022-02-25

  

  Although, GABA-C receptors were originally described in the spinal cord [16], clues to their physiological function arise mainly from studies in the visual system [5], [26]. In mammals, GABA-C receptors are found abundantly in cone photoreceptors and bipolar cell axon terminals, where they participa

• br FAAH mediation of fear and extinction In addition to

  2022-02-24

  

  FAAH mediation of fear and extinction In addition to being a major target and modulator of stress, the BLA is a critical node within the neural circuitry subserving learned fear behaviors. The BLA is activated during the formation, expression, and extinction of conditioned fear memories, and dama

• To date three other allosteric binding sites

  2022-02-24

  

  To date, three other allosteric binding sites of HIV-1 IN have also been reported. In the work of Wielens and co-workers [33], a pocket formed by the residues Tyr83, Trp108, Asn184, Ile200 and Val201 was found, which can be bound by small molecules. In the work by Rhodes et al. [34], a small-molecul

• br Materials and methods br Results br

  2022-02-24

  

  Materials and methods Results Discussion In the absence of vascularization phenomena, endothelial cells (ECs) are among the most quiescent cells of the body [27]. ECs proliferation is significant during embryogenesis, as the vasculature is being formed, while in the adult life takes place o

• The Jumonji JmjC domain containing KDM family members can

  2022-02-24

  

  The Jumonji (JmjC) domain-containing KDM family members can be clustered into seven subfamilies (KDM2 – KDM8). The KDM2 cluster catalyzes H3K36me2/me1 demethylation; in addition, KDM2B/JHDM1B/FBXL10 has been suggested to catalyze demethylation of H3K4me3 [3]. Cell culture studies support that KDM2 p

• br Introduction Adenosine triphosphate ATP is an organic mol

  2022-02-24

  

  Introduction Adenosine-5′-triphosphate (ATP) is an organic molecule (nucleoside triphosphate) which consists of adenine, ribose, and three phosphoric trk receptor residues. ATP serves as a temporary carrier of energy in all living cells, so it is a common substance in any organism. In the cells,

• In addition to changes in the Rho isoforms all

  2022-02-24

  

  In addition to changes in the Rho isoforms, all Rac isoforms, including the constitutively active splice variant of Rac1, Rac1b, are overexpressed in various tumors and accumulating evidence indicates that they play an important role in the metastatic potential of cancer Carmustine (Chan et al., 200

• The NF B family of transcription factors is involved

  2022-02-24

  

  The NF-κB family of transcription factors is involved in acquisition of resistance to anticancer drugs as well as to apoptosis. NF-κB-mediated mdr1 gene upregulation is part of the anti-apoptotic protection mechanism of proximal tubule (PT) NVP-AEE788 against cadmium-induced oxidative stress and ap

• br The mode of binding of ligands to GPR As

  2022-02-24

  

  The mode of binding of ligands to GPR35 As noted above, although kynurenic SANT-1 is an agonist at GPR35, this is true for neither kynurenine [8] nor kynurenic acid ethyl ester [13]. This implicates a key role for the carboxylate group in binding and/or activation of GPR35. Importantly, in studi

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