• br Conclusions br Declarations br Introduction The classical

  2024-12-02

  

  Conclusions Declarations Introduction The classical term of endocrine disruption includes any agent that interferes with the action of hormones within the human body; these agents are therefore named endocrine disruptors. Among these agents, that are mainly environmental chemicals (pollutan

• Clinical observations of individuals with a

  2024-11-29

  

  Clinical observations of individuals with a decrease in 12-LOX Sulindac sulfide are consistent with 12-LOX potentiating platelet activation and thrombus formation [40]. However, the relative contribution of 12-LOX to these complex disorders cannot be fully elucidated in the absence of a biochemical

• So far many independent studies have linked

  2024-11-29

  

  So far, many independent studies have linked cholesterol metabolism–related genes with AD, either by showing associations with specific polymorphisms or with differential tyramide signal amplification levels (Beecham et al., 2014, Blain and Poirier, 2004, Lambert et al., 2009, Lambert et al., 2013,

• br Conclusion br Conflict of interest br Acknowledgements br

  2024-11-29

  

  Conclusion Conflict of interest Acknowledgements Introduction Human salivary aldehyde dehydrogenase (hsALDH) (E.C. 1.2.1.5) is the first line of defence against toxic aldehydes in the oral cavity. HsALDH is primarily a dimeric, class 3 ALDH (ALDH3A1) specific for aromatic and long/medium

• Adenosine is an endogenous nucleoside that plays pivotal

  2024-11-29

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the NU7441 and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors (

• Chlorpropamide receptor Oxidative stress has recently been r

  2024-11-29

  

  Oxidative stress has recently been reported as one of the important mechanisms of toxic effect of Cd2+[43]. The mechanism of Cd2+-induced oxidative stress involves an imbalance between generation and removal of ROS in tissues and cellular components, causing damage to membranes, DNA, and proteins [4

• br Materials and methods br Results br Discussion

  2024-11-29

  

  Materials and methods Results Discussion Cdc42 has been implicated in mediating the entry of HCV into hepatocytes, but how Cdc42 affects the response of HCV patients to IFN therapy is unknown. This study therefore examined the genetic association between Cdc42-related genes and efficacy of

• The pathogenesis of d penicillamine induced MG is

  2024-11-29

  

  The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR mass of cl in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20% of d-pen

• br Experimental section br Results

  2024-11-29

  

  Experimental section Results and discussion Conclusion Acknowledgements This work was financially supported by Recruitment Program of Global Experts, and the Director Foundation of XTIPC, CAS, Grant No. 2015RC011. This work was also financially supported by Natural Science Foundation of

• REM sleep is proposed to create an environment to

  2024-11-29

  

  REM sleep is proposed to create an environment to facilitate plasticity processes that create a generalized downregulation of synaptic strength (Grosmark et al., 2012; Tononi and Cirelli, 2014), while synapses are upregulated specifically by the reactivation of neuronal firing sequences experienced

• 2-Palmitoylglycerol br Methods br Results From a study

  2024-11-29

  

  Methods Results From a study population of 7069 patients, a total of 149 falls were reported during the study 2-Palmitoylglycerol for an incidence rate (IR) of 5.2 falls per 1000 patient-days (PD), 95% confidence interval (CI) 4.4/1000 PD–6.1/1000 PD. The incidence rate ratio (IRR) for patien

• br Regulation and pharmacology of mPGES mPGES kDa amino acid

  2024-11-29

  

  Regulation and pharmacology of mPGES-1 mPGES-1 (16 kDa, 152 amino acids) is a trimeric integral membrane protein of the endoplasmic reticulum with each monomer containing four transmembrane domains (Samuelsson et al., 2007; Sjogren et al., 2013). The three active site cavities are located at the

• In an effort to determine if one ARI was more

  2024-11-29

  

  In an effort to determine if one 5ARI was more effective than the other, the Enlarged Prostate International Comparator Study (EPICS) [17] compared treatment with finasteride and dutasteride in 1630 men over the age of 50 and concluded that after one year of treatment, both groups had statistically

• For both the hydroxylation and lyase reactions

  2024-11-29

  

  For both, the 17α-hydroxylation and 17, 20-lyase reactions, the heme iron center of P450 17A1 receives electron reducing equivalents from CPR. Both reactions require one pair of electrons and molecular oxygen for the conversion of the substrate into product in each catalytic cycle. However, the 17,2

• br Conclusion br Acknowledgments This research

  2024-11-29

  

  Conclusion Acknowledgments This research has been supported by the Ratchadaphiseksomphot Endowment Fund 2013 of Chulalongkorn University (CU-56-341-AS) and the Ratchadapiseksompotch Fund (RA55/22), Faculty of Medicine, Chulalongkorn University. The authors commemorate the 100th Anniversary of

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