• Eicosanoids are locally acting signaling lipids

  2023-05-25

  

  Eicosanoids are locally acting signaling lipids that are produced from C20 polyunsaturated fatty acids (PUFAs), including arachidonic Salmeterol xinafoate (AA, C20:4), eicosapentaenoic acid (C20:5) and eicosatrienoic acid (C20:3) (Dennis and Norris, 2015; Funk, 2001; Stables and Gilroy, 2011). Acco

• Prostate cancer is the second leading cause

  2023-05-25

  

  Prostate cancer is the second leading cause of cancer-related death in men in the United States [25]. Similar to pancreatic cancer, prostate cancer has few diagnostic options available, particularly to differentiate indolent from aggressive disease. Axl is also overexpressed in ∼50% of prostate canc

• The present study has several limitations First

  2023-05-25

  

  The present study has several limitations. First, the results were obtained using RAW264.7 cells, which are derived from BALB/c mice infected with the Abelson leukemia virus (Raschke et al., 1978). However, these cells, which are a commonly used mouse macrophage cell line, show properties similar to

• NOXA a member of the pro apoptotic B

  2023-05-25

  

  NOXA, a member of the pro-apoptotic B-cell lymphoma 2 (BCL-2) family, plays a vital role in regulating mitochondrial or inherent apoptotic pathways [7,8]. NOXA binds to MCL-1 with high affinity and interacts with A1 (known as BCL2A1), resulting in BIM release to trigger subsequent apoptosis [9]. In

• Recent studies showed that the increased expression of Auror

  2023-05-25

  

  Recent studies showed that the increased expression of Aurora B kinase directly proportional to the tumor invasion and metastasis [61]. The Aurora B kinase regulates the PI2K/Akt signaling pathway has a significant role in tumor invasion and metastasis that leads to phosphorylation of GSK3β on ser 9

• Along with the improvement of the cadmium transport from roo

  2023-05-25

  

  Along with the improvement of the cadmium transport from roots to aerial tissues, as is required for phytoremediation, over-expression of PtoHMA5 also led to the excessive accumulation of cadmium in leaves that was harmful to plant growth and physiological performance. Thus, detoxification of the he

• Although the earlier studies focused on the antioxidant

  2023-05-24

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic Tanshinone IIA---sulfonic sodium and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiq

• br Antiangiogenic therapy in non small

  2023-05-24

  

  Antiangiogenic therapy in non-small cell lung cancer (NSCLC) Antiangiogenic targeted therapy is an area of active research in which numerous agents have been studied and have been shown to be effective for many tumor types including NSCLC. Angiogenesis is frequently upregulated in malignant solid

• Finally microRNAs miRNA seem to play

  2023-05-24

  

  Finally, microRNAs (miRNA) seem to play an important role in AR signaling in BC. Some authors have described a differential BMS-303141 of miRNAs in AR-positive BCs compared to AR-negative ones. VEGF and mTOR pathways were also reported as implicated in miRNA dysregulation, suggesting a common under

• br Discussion Hepatic dysfunction in the metabolic syndrome

  2023-05-24

  

  Discussion Hepatic dysfunction in the metabolic syndrome is a driver of negative patient outcomes that requires more therapeutic options. The complexity of liver alterations in this disease – elevated de novo synthesis of fatty acids and cholesterol, reduced clearance of circulating atherogenic L

• Alectinib is a second generation ALK antagonist that is

  2023-05-24

  

  Alectinib is a second generation ALK antagonist that is built upon a 9-ethyl-6, 6-dimethyl-11-oxo benzo[b]carbazole scaffold (Fig. 5C) [58]. This drug is effective against the ALK L1196M gatekeeper mutation along with C1156Y and F1174L mutations [7]. The 11-oxo group of the drug forms a CO-1686 wit

• br Impact of global AHR deficiency on diet induced obesity

  2023-05-24

  

  Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s

• To examine whether the interaction between mGlu and adrenerg

  2023-05-24

  

  To examine whether the interaction between mGlu7 and α1-adrenergic receptors could be confirmed at a behavioural level, we performed the FST in mice. This test has value in predicting the antidepressant-like effect of drugs or environmental manipulations (Krishnan and Nestler, 2008, Krishnan and Nes

• As the close paralog of adiponectin we

  2023-05-24

  

  As the close paralog of adiponectin, we hypothesized that CTRP9 could participate in regulation of reproduction. In order to evaluate whether Ctrp9 plays a role in the control of reproduction in tilapia, i.p. injection experiment was performed. HPG (Hypothalamic/pituitary/gonadal) axis plays a key r

• The relatively high concentration of HT

  2023-05-24

  

  The relatively high concentration of 5-HT used in this study (100 µM) is consistent with the concentrations used in other published ex vivo studies (Ropert and Guy, 1991, Passani et al., 1994, Shen and Andrade, 1998). In our paradigm 5-HT was focally applied at the surface of the slice via a fast pe

15741 records 297/1050 page Previous Next First page 上5页 296297298299300 下5页 Last page