• In chicken ovary the adiponectin

  2023-01-29

  

  In chicken ovary, the adiponectin gene was found to be mainly expressed in theca cells and is suggested to exert a paracrine or autocrine effect on ovarian steroidogenesis (Chabrolle et al., 2007). A limited number of studies have revealed the effect of adiponectin on ovarian steroidogenesis or its

• Whether similar mechanisms play a role in adiponectin signal

  2023-01-29

  

  Whether similar mechanisms play a role in adiponectin signal transduction and whether additional proteins are recruited to adiponectin receptors via APPL1 has not been analysed so far. Although it has been clearly established that APPL1 is a downstream adaptor protein in adiponectin signal transduct

• The purpose of the present study is to

  2023-01-29

  

  The purpose of the present study is (1) to characterize AChE from the monogonont B. koreanus and to analyze the modulation of the AChE activity and its transcription level after exposure to six pharmaceuticals, (2) to evaluate the usefulness of AChE as a molecular biomarker upon pharmaceutical expos

• br LOX in pancreatic cancer LOX is

  2023-01-29

  

  5-LOX in pancreatic cancer 5-LOX is a key player in pancreatic cancer (PC) progression. The upregulation of 5-LOX mRNA has been observed in pancreatic adenocarcinoma (PDAC) and also in neoplastic pancreatic tissues (Kennedy et al., 2003). Higher levels of 5-LOX transcripts (messengers) are presen

• Earlier studies showed that exposure of cells to IR caused

  2023-01-29

  

  Earlier studies showed that exposure of cells to IR caused ATM-dependent phosphorylation of 53BP1, as judged by electrophoretic mobility shift [24], [25], [26]. To date, the only known in vivo 53BP1 phosphorylation site(s) are Ser25 and possibly Ser29 [27]. In the course of our studies, we noticed t

• rucaparib synthesis It is well known that neurosteroids such

  2023-01-29

  

  It is well-known that neurosteroids such as testosterone and their metabolites endogenously modulate neural excitability in animals and humans. Testosterone has protective effects against seizures induced by KA and PTZ (Frye et al., 2001b; Reddy, 2004b). Estrogens, on the other hand, have proconvuls

• INK 128 The physiologic conditions and signaling mechanisms

  2023-01-29

  

  The physiologic conditions and signaling mechanisms that regulate apelin secretion and APLNR expression in malignant tissues appear to be multifactorial. Previous studies have shown that hyperplastic and neoplastic cholangiocytes secrete a variety of hormones, peptides, and growth factors that help

• Recently different kinds of A aggregation inhibitors have

  2023-01-29

  

  Recently, different kinds of Aβ aggregation inhibitors have been reported, including small molecules [8], peptides [9], and nanoparticles (NPs) [10]. The working mechanisms of the inhibitors are mostly to bind or adsorb Aβ molecules and to affect the conformational changes followed by blocking the a

• The reactions and the control mechanisms described are all

  2023-01-28

  

  The reactions and the control mechanisms described are all supported by observations. For example the reactions require that different compounds are formed in different groups of GSK2879552 cells and this has been observed [15]. Intravenous injection of glycine results in reduced utilisation of glu

• To guide our attempts at achieving AKT potency and selectivi

  2023-01-28

  

  To guide our attempts at achieving AKT potency and selectivity against p70S6K and other kinases from (p70 S6K IC: 0.004 μM) and , we took advantage of exploiting the subtle sequence differences in the active sites of the AGC family kinases, we utilized the information around crystal structure of AK

• PKA signalling in the http www apexbt

  2023-01-28

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the Fluorescein-12-dUTP to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleu

• While the direct effects of ARI lead

  2023-01-28

  

  While the direct effects of 5-ARI lead to a dramatic glutathione reductase in serum DHT levels, other laboratory values are also affected by 5-ARI use. Serum testosterone elevations are known to occur with both finasteride and dutasteride use, but values will typically remain within the normal labo

• Fig summarizes the oxidative metabolism of arachidonic acid

  2023-01-28

  

  Fig. 1 summarizes the oxidative metabolism of arachidonic AMTB hydrochloride by lipoxygenases cyclooxygenases and cytochrome P450. Lipoxygenases in humans are expressed in a tissue-specific fashion: 5-LOX is mainly expressed in leukocytes, 12-LOX in platelets, and 15-LOX-1 in reticulocytes, eosino

• How does the ATM to ATR switch occur at

  2023-01-28

  

  How does the ATM-to-ATR switch occur at DSBs? The progressive attenuation of ATM activation could be attributed to the loss of DNA structures that activate ATM, or to the generation of DNA structures that interfere with ATM activation. Our finding that SSOs do not directly affect the binding of puri

• There are essentially two screening strategies to minimize

  2023-01-28

  

  There are essentially two screening strategies to minimize the number of newborns recalled for additional testing without missing cases for most screening disorders. For hyperargininemia, one strategy uses Arg alone as the indicator of possible disease and the other uses Arg in combination with a ra

15116 records 285/1008 page Previous Next First page 上5页 281282283284285 下5页 Last page